Why Some People Don’t Develop Bipolar Disorder Despite High Genetic Risk

Bipolar disorder, which affects approximately 5.7 million Americans age 18 and older every year , tends to run in families. Siblings, in particular, are 10 times more likely to develop the illness, compared with the general population. Yet many siblings of bipolar people do not develop the condition. Why not? Researchers from the Icahn School of Medicine at Mount Sinai Hospital in New York have identified a brain mechanism in siblings of bipolar patients that makes them resilient to bipolar disorder.

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