New Insight Into How Autism Might Develop in Human Brain

New Insight Into How Autism Might Develop in Human Brain

In a study published in Stem Cell Reports, a McGill team of scientists revealed a molecular mechanism that may play a role in the development of autism. By taking skin cells from patients and reprogramming those cells to become brain cells through genetic engineering, they tracked how a brain cell with the patient's own mutation develops improperly. The team focused on a gene named GRIN2B, a gene known to cause autism when mutated. Almost all genes in humans have two copies. A mutation in one copy of GRIN2B is sufficient to cause moderate intellectual disability and autism. "The protein, made...

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