Lamotrigine Similar to Placebo in Treating Borderline Personality Disorder

Lamotrigine Similar to Placebo in Treating Borderline Personality Disorder

The findings of a double-blind, randomized, controlled trial published in the American Journal of Psychiatry suggest that the anticonvulsant lamotrigine is not cost-effective or clinically effective as a therapy for borderline personality disorder. Up to 90% of patients with borderline personality disorder are treated with psychiatric medication. Mood stabilizers like lamotrigine are intended to mitigate aggression toward oneself and others. Lamotrigine is already approved for the treatment of bipolar disorder and has been noted for its relative safety. The authors identified 276 adults with borderline personality disorder, excluding patients with a concurrent psychotic or bipolar disorder, those already taking a mood stabilizer,...

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