Schizophrenia, Depression, Bipolar Disorder Linked With Abnormal Functional Connectivity

Schizophrenia, Depression, Bipolar Disorder Linked With Abnormal Functional Connectivity

Abnormal functional connectivity has been identified in individuals with schizophrenia, major depressive disorder, and bipolar disorder, according to a study published in the Journal of Affective Disorders . These abnormalities include an imbalance between network segregation and integration. This single-site study included 126 individuals with schizophrenia, 97 with bipolar disorder, 126 with major depressive disorder, and 188 in a healthy control group, all of whom were administered functional magnetic resonance imaging in resting state. The bilateral orbital frontal cortex, as well an additional region in its left orbital frontal cortex reaching the putamen, showed heightened functional connectivity across all 3 disorders...

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