This Study Highlights The Genetic Changes In The Brain From Cocaine Use

This Study Highlights The Genetic Changes In The Brain From Cocaine Use

A study in Biological Psychiatry has identified unique genetic changes in the brain's reward circuitry that are associated with cocaine use, including first-time use, withdrawal, and re-exposure to the drug after prolonged withdrawal. The findings reveal important information on how cocaine addiction reprograms gene expression and provide insight into the molecular basis of cocaine addiction in unprecedented detail. In the study, mice were allowed to self-administer cocaine as a model of human addiction, and the gene expression changes were associated with their addiction-like behavior. "This study elegantly highlights the complexity of the brain's molecular response to self-administered cocaine, pointing to...

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