This Trial Studies the Effects of Memantine and Ketamine on Adults With OCD

This Trial Studies the Effects of Memantine and Ketamine on Adults With OCD

The only first-line pharmacological treatments recommended for obsessive-compulsive disorder (OCD) are serotonin reuptake inhibitors (SRIs). We found that a single IV dose of ketamine rapidly decreases symptoms in unmedicated patients with OCD, demonstrating that a drug affecting glutamate transmission can reduce OCD symptoms without an SRI. After study participation, patients often requested a drug with similar effects to ketamine that could be taken as an outpatient. Memantine shares a similar mechanism of action as ketamine (ie NMDA glutamate receptor antagonism.) It has been shown to decrease OCD symptoms in some when given orally over 12 weeks. Given memantine is available in oral dosing...

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