A New View of the Changes in Brain Activity Created By Electrical Stimulation

A New View of the Changes in Brain Activity Created By Electrical Stimulation

Repetitive transcranial magnetic stimulation (rTMS) is increasingly used in patients with disorders such as depression that do not respond well to medication or psychotherapy. Although the effects of stimulation on the motor cortex have been characterized in animal models and humans, its effects on other brain areas -- including the prefrontal cortex, the target of rTMS in depression -- are unclear. Corey Keller and colleagues mimicked rTMS of the prefrontal cortex in four epileptic patients who were previously implanted with brain electrodes to manage their condition. This allowed the researchers to study changes in the neural activity of specific regions...

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