Study Offers New Approach to Starve p53 Deficient Tumors

Study Offers New Approach to Starve p53 Deficient Tumors

One major hallmark of cancer cells is their ability to adapt to stressful conditions such as nutrient deprivation. Rapidly growing tumor cells must compete for the ever-diminishing supply of nutrients in the surrounding environment to survive and proliferate. Targeting these adaptive mechanisms represents a promising approach for cancer therapeutics. Sanford Prebys Medical Discovery Institute (SBP) researchers recently discovered an alternative metabolic pathway that might be used by cancer cells to survive nutrient deprivation. As reported May 3 in the journal Molecular Cell , two proteins belonging to the PI5P4K family of enzymes-- PI5P4Kα and PI5P4Kβ --are critical for a process...

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