Nasal spray of party drug shows promise as fast-acting antidepressant, researchers say

The latest clinical trial of esketamine, the nasal-spray form of the club drug ketamine, is boosting confidence among some psychiatrists that it could be a major advance in the treatment of suicidal depression. In a study published this week in the American Journal of Psychiatry, researchers report that an esketamine trial resulted in a “rapid improvement in depressive symptoms” in people with severe, treatment-resistant depression. Forty-nine patients completed the four-week trial. Doses were administered twice weekly, and the esketamine quickly showed an effect. Just four hours after the initial dose, people receiving the drug experienced a significant reduction in depressive...

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