Neurons derived from super-obese people respond differently to appetite hormones

US scientists have successfully generated hypothalamic-like neurons from human induced pluripotent stem cells (hiPSCs) taken from the blood and skin cells of super-obese individuals and people with a normal body weight. The researchers found that the brain cells derived from the super obese were more likely to dysregulate hormones related to feeding behavior and hunger, as well as obesity-related genes and metabolic pathways. The work appears April 19th in the journal Cell Stem Cell . "This is the first step in applying an iPSC-based platform to model complex polygenic diseases such as obesity," says senior author...

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