Under-diagnosis of alcoholic ketoacidosis may be fatal - A major concern. Re: Alcoholic ketoacidosis: an underdiagnosed condition?

Under-diagnosis of alcoholic ketoacidosis may be fatal - A major concern. Re: Alcoholic ketoacidosis: an underdiagnosed condition?

We read with interest the research article expressing apprehension that alcoholic patients with alcoholic ketoacidosis are underdiagnosed (1).There is increasing evidence that rather than being benign and self-limiting, alcoholic ketoacidosis may be a significant cause of mortality in patients with alcohol dependence(2). Background: Alcoholic ketoacidosis is characterised by metabolic acidosis with an elevated anion gap, elevated serum ketone levels, and a normal or low glucose concentration.(2.3) Alcohol dehydrogenase (ADH), a cytosolic enzyme, metabolizes alcohol to acetaldehyde in hepatocytes. Acetaldehyde is metabolized further to acetic acid by aldehyde dehydrogenase producing significantly higher beta-hydroxybutyric acid with other ketone bodies, which in turn,...

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