Risk of type 1 diabetes climbs when one population of T cells falls

In autoimmune diseases such as type 1 diabetes, some of the immune system's T cells mistakenly attack the body's own cells, while protective T regulatory cells try to defend against that attack. Scientists at Joslin Diabetes Center have shown in a mouse model of type 1 diabetes that animals with fewer of a poorly studied type of T regulatory cells are much more likely to develop the disease. Most T regulatory cells develop and mature in the thymus, a small lymphatic organ above the heart, says Stephan Kissler, Ph.D., an Investigator in Joslin's Section on Immunobiology. But a small population...

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