β-Blockers After a Heart Attack

β-Blockers After a Heart Attack

Two large observational studies published last year in the Journal of the American College of Cardiology (JACC) are raising questions about the need for β-blockers in all patients after a first heart attack. Both found a limited mortality benefit associated with use of β-blockers in certain clinical scenarios, underscoring the need for randomized clinical trials (RCTs) designed to test the effectiveness of these historical drugs in the contemporary era, the researchers said. β-Blockers were approved in the 1980s for use in patients recovering from myocardial infarction (MI) after 2 large RCTs—the β-Blocker Heart Attack Trial (BHAT) and the Norwegian Multicenter...

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