Are the risks of treatment to cure a child with severe sickle cell disease too high?

Haematopoietic stem cell transplantation from alternative donors is curative for children with sickle cell disease, but risk of death is high. David Rees and colleagues call for greater caution in its use Sickle cell disease is one of the most common severe inherited conditions in the world. Around 300 000 babies are born with sickle cell disease each year, mostly in Africa, although there are roughly 100 000 affected people in the US and 50 000 in Europe.1 The prognosis for children born with the condition today varies enormously, particularly with geography: only about 20% of babies born in Africa...

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