Sertraline Monotherapy May Not Be Enough for Patients With Complicated Tbi, Mdd

Sertraline Monotherapy May Not Be Enough for Patients With Complicated Tbi, Mdd

More than 50 percent of patients with traumatic brain injury (TBI) may develop major depressive disorder (MDD), but it is still unclear how antidepressants can best be used for this population. So far, studies show that the selective serotonin reuptake inhibitor (SSRI) sertraline is more effective in preventing, rather than treating, depression in people with TBI. A 2016 JAMA Psychiatry study found when sertraline was used as a preventive agent soon after a TBI, only 6 percent of participants taking the medication (100 mg/day) developed MDD after 24 weeks, compared with 22 percent in the placebo group. A study published...

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