Neonatal Hypoglycemia Rates in Glyburide vs Insulin Treatment for Gestational Diabetes

Glyburide and insulin are equally effective for treating women with gestational diabetes, according to a meta-analysis published in PLoS ONE . 1 However, incidence of neonatal hypoglycemia was greater among infants whose mothers used glyburide vs insulin. Researchers from Shanghai Jiaotong University School of Medicine Xinhua Hospital in Shanghai, China, reviewed 3 large databases and examined 10 randomized controlled trials that met study inclusion criteria. Of all women with gestational diabetes (n=1194), 575 used glyburide and 619 used insulin. Maternal glycemic control was not significantly different between the 2 treatment groups.

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