It’s not uncommon for people with chronic kidney disease (CKD) to also suffer from depression, which can worsen a patient’s health. A new clinical trial published in JAMA found that the antidepressant sertraline, commonly known as Zoloft, doesn’t help improve symptoms of major depressive disorder in patients with CKD.
The clinical trial compared the effects of sertraline to those of a placebo and found that there was no significant difference in effectiveness between them. As a consequence, sertraline may not be recommended as a treatment for depression in people with non–dialysis-dependent CKD.
Source: JAMA. 2017;318(19):1876-1890. doi:10.1001/jama.2017.17131